Wild pigs are the most abundant wild exotic ungulate in the United States. In Texas, particularly, they are abundant and represent a threat to ecosystems, agriculture and humans. Our objective was to apply a landscape-scale analysis of population genetic structure of wild pigs to aid in their management in southern Texas. We used microsatellites to assist large-scale applied management. We found that some populations were isolated from one another. However, many individuals and local populations were admixed, which indicates that multiple introductions and artificial movement of individuals has occurred. Wild pig management efficiency and effectiveness may be able to improve if illegal translocations stop (e.g., enforcing laws) and if management cooperatives are created to manage spatially extensive areas of southern Texas.